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Interestingly, after a week-long suppression of the gut microbiota with oral broad-spectrum antibiotics cocktail, a rechallenge with oral d 9 -γBB showed complete suppression of d 9 -TMAO formation in subjects, confirming gut microbiota–dependent conversion of γBB into TMAO (Figure 2A, open circles)
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A number of studies have used the ratio of acylcarnitines to free carnitine as an index of carnitine homeostasis [19, 20, 53, 54, 93]