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Immunotherapies and cell therapies associated with senolytic activity Regulation of the immune system The senescent process directly impacts the cells in which this biological mechanism is activated but also the surrounding cells through the SASP or specific proteins expression at the plasma membrane

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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy