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The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period
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Notably, both angiogenesis [50,51] and the NO-system [52,53,54,55,56,57] have been fundamental for healing since quite early in the cytoprotection concept