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The number of gut microbiota-specific Th17 cells, such as those specific to Candida albicans, increases during ALD, and these cells migrate to the liver, further amplifying the inflammatory response [100]
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Moreover, in a rare kidney cancer (chromophobe renal cell carcinoma), the absence of GGT1 function renders these cells exquisitely dependent upon extracellular cystine for survival relative to normal tissues 62
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